One hundred and seventy-two pedigrees containing 1548 individuals were used in the genetic analyses. Of these, 584 individuals were from 106 extended families where multiple family members were directly interviewed, data from these individuals were used to calculate heritability of the phenotypes. Sixty-six additional families have only a single individual with direct interview data. The individuals in these 66 families were not included in the linkage analyses but were included in the co-morbidity analyses and in the calculation of trait means and variance in order to determine the impact of covariates. Four hundred and sixteen individuals from 81 extended pedigree families have both genotype and phenotype data and were used in the linkage analyses. The family sizes for the 81 families ranged between 4 and 41 members (average 13.9±8.9) with between 2 and 15 individuals having both genotype and phenotype data (average 5.0±3.3). The 416 individuals within the 81 families that were genetically informative include: 142 parent-child, 260 sibling, 53 half-sibling, 11 grandparent-grandchild, 235 avuncular, and 240 cousin relative pairs. Only sib, half-sib, avuncular and cousin pairs were included as
