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Chunk #13 — Results — GluA1 and PSD-95 mRNA expression are strongly correlated in the amygdala of drug abusers

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Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers.
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Blood morphine levels were not significantly correlated with the mRNA expression levels, but blood cocaine concentrations in the cocaine group were significantly correlated with amygdala levels of GluA1 (basal parvocellular division, r=0.9723, p=0.0011; lateral r=0.7745, p=0.0409) and Homer (lateral nucleus, r=0.8867, p=0.0078). No association to cocaine and cocaine metabolite levels was evident in the heroin-cocaine subjects which could be due to their lower blood cocaine and benzyloecognine concentrations as compared to the cocaine only group (Table 1).