Participants provided samples of either peripheral blood (n = 191) or buccal swab (n=165). The ALDH2 Glu504Lys polymorphism (rs671) was genotyped using an Applied Biosystems TaqMan drug metabolism genotyping assay (Foster City, CA, USA). Additional details regarding the genotyping procedure have been previously published (Irons et al., 2007). Of 356 genotyped samples, 260 (73%) were homozygous ALDH2*1/*1, 87 (24.5%) were heterozygous ALDH2*1/*2, and 9 (2.5%) were homozygous ALDH2*2/*2. These genotype proportions did not deviate from Hardy Weinberg equilibrium, X2(1) = 0.28, p = 0.6. The frequency of the ALDH2*2 allele that we observed (14.8%) was approximately equivalent to previous studies of the polymorphism in samples of Korean descent (Li et al., 2009; Luczak, et al., 2006). ALDH2 genotype did not vary by sex, X2(1) = 1.87, p = .17.
