First, we performed the primary 30 cM bin width GSMA over all independent genome scans on smoking behavior, encompassing 3404 families with 10,253 genotyped subjects. Figure 1 illustrates the weighted and unweighted PSR for all bins across the genome. The full details of genetic regions showing bins with nominal significance in weighted analysis are shown in Table 2, and the unweighted analysis results are also included as a comparison with weighted analysis. The strongest evidence for a smoking behavior risk locus was found on chromosome 17q24.3–q25.3 (bin 17.4) where suggestive evidence for linkage was achieved by either unweighted (PSR = 0.002) or weighted analysis (PSR = 0.001).
