same amount of the variance in these traits (e.g. ∼19% of the variance in AD) as either ADH1B-rs1229984 (∼18% of the variance in AD) or ADH1C-rs698 (∼17% of the variance in AD) individually, considering these SNPs together provides a model that more accurately describes the polygenic architecture of these traits. Thus, the higher effect sizes (ORs or RRs) in the diplotype analysis (for the high vs. low risk comparison) than in the single marker analyses was most likely due to better characterization of the gene effect due to partitioning the ADH1B-rs1229984 high risk group into two groups based on the presence or absence of the ADH1C-rs698 high risk group.
