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Chunk #35 — DISCUSSION

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
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callosal fibers in the posterior parietal segment on psychiatric symptom. However, these results should be interpreted cautiously because there was no significant difference in FA of callosal fibers in the posterior parietal segment between the SZ and HC groups. There has been no consensus on the relationship between white matter abnormalities and psychiatric symptoms of schizophrenia. With regard to FA values of the CC and psychiatric symptoms, study results are inconsistent. They reported FA values of the anterior CC and negative correlation with both negative symptoms (Gu et al., 2016; Kubicki et al., 2008; Nakamura et al., 2012) and positive symptoms (Knöchel et al., 2012; Kubicki et al., 2008). FA values of the posterior CC were negatively correlated with negative symptoms (Rigucci et al., 2013), negatively correlated with positive symptoms (Kubicki et al., 2008), but positively correlated with positive symptoms (Rotarska‐Jagiela et al., 2009). FA values of other white matter fibers have also been reported to have inconsistent directions of association, with studies reporting positive correlations with both positive (Andreasen et al., 2011; Chan et al., 2010; Cheung et al., 2011; Choi et al., 2011; Lee et al., 2013; Moriya et al., 2010; Psomiades et al., 2016; Rotarska‐Jagiela et al.,