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Chunk #14 — Materials and Methods — Statistical analysis — Power evaluation

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Association of CHRNA4 polymorphisms with smoking behavior in two populations.
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genetic model with MAF = 0.1 (0.3), the CPD sample (N = 915) had 54% (89%) power to detect a main effect of 0.1. For the two binary traits in EAs, under a log-additive genetic model with MAF = 0.1 (0.3), our study had 66% (94%) and 63% (93%) power to detect an effect with a relative risk of 1.5 for ND (716 cases/223 controls) and FTND (705 cases/208 controls), respectively.