Two genome-wide association studies (GWAS) of AN have been conducted. One study that used DNA pooling and genotyping with a modest number of microsatellite markers with follow-up genotyping detected evidence for association with rs2048332 on chromosome 1, but this finding did not reach genome-wide significance.41 A GWAS of 1033 AN cases from the USA, Canada, and Europe compared with 3733 pediatric controls yielded no genome-wide significant findings.42 Recently, a sequencing and genotyping study of 152 candidate genes in 1205 AN cases and 1948 controls suggested a novel association of a cholesterol metabolism influencing EPHX2 gene with susceptibility to AN.43
