DNA samples (primarily from peripheral blood) from over 50,000 people genotyped for the Gene-Environment Association Studies (GENEVA) consortium16 were analyzed to detect clonal mosaicism. The GENEVA studies include all ages from birth to old age, several major ethnic groups, and a variety of different health conditions, including healthy controls (Table 1, Supplementary Table 1, Supplementary Fig. 1). Here we characterize the types of chromosomal anomalies detected, show how the prevalence of detectable clonal mosaicism within blood cells increases with age, and examine the association between mosaic anomalies and hematological cancer.
