The cumulative probability estimates of dependence remission within the first year of dependence onset were 3.0% for nicotine and alcohol, 4.7% for cannabis, and 8.6% for cocaine. The cumulative probability of remission a decade after onset of dependence was 18.4% for nicotine, 37.4% for alcohol, 66.2% for cannabis, and 75.8% for cocaine. Lifetime cumulative probability estimates of dependence remission were 83.7% for nicotine, 90.6% for alcohol, 97.2% for cannabis, and 99.2% for cocaine. Half of the cases of nicotine, alcohol, cannabis and cocaine dependence remitted approximately 26, 14, 6 and 5 years after dependence onset, respectively (Figure 1).
