alcohol vs control taste period. For comparisons between genotype groups, these contrast maps were then registered to a high-resolution image using FMRIB’s Linear Image Registration Tool. A priori region-of-interest anatomical masks were created using previously described methods35 for the NAcc/ventral striatum, the VTA, the orbitofrontal cortex (OFC), and the ventromedial PFC (VMPFC). Group-level analysis was performed using FLAME (FMRIB’s Local Analysis of Mixed Effects) stage 1 only (ie, without the final Markov Chain Monte Carlo–based stage).41,42 Z (gaussianized T/F) statistical images were thresholded using gaussian random field theory–based maximum height thresholding with a significance of P = .05.43
