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Chunk #27 — Strengths and limitations

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The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders.
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Identification of cases within the iPSYCH2012 sample is based on contacts to in- and out-patient psychiatric departments and visits to psychiatric emergency care units in a nation where treatment is provided through the government healthcare system free of charge, and where no private psychiatric hospitals exist. Financial factors are thus less likely to influence pathways to healthcare in Denmark compared to many other nations.82 Unlike samples of convenience, the iPSYCH2012 sample is representative of the Danish population irrespectively of (a) recall bias, (b) emigration or death before sampling, (c) institutional care, (d) imprisonment, (e) being homeless, (f) health and (g) socioeconomic status.26 In contrast to most genetic studies, the iPSYCH2012 sample also provides the unique possibility to explore the potential impact of the longitudinal trajectory on causes and outcomes of mental disorders.