Chunk #14 — Results — Total CHRNA5 mRNA level in frontal cortex is strongly associated with variants located upstream of the gene in individuals of both African and European ancestry
Similar to our previous study in human brains of European ancestry [19], [20], the variability in CHRNA5 total mRNA expression levels in frontal cortices of African ancestry is significantly associated with rs880395 (p = 7.27×10−7), rs3841324 (p = 6.94×10−3), and rs588765 (p = 1.10×10−4) (Table 1). Subjects homozygous for the minor allele at rs880395 and rs3841324, and rs588765 showed 5.4-fold, 2.6-fold, and 4.7-fold increase in CHRNA5 mRNA expression levels compared to the major allele homozygotes, respectively (Figure 1).
