Lastly, we used the JEPEGMIX2-P software [66] with default settings to conduct TWAS using only the 13 brain-specific GReX models coming from GTeX v8 [67]. This method was preferable since it relied on a covariance matrix based on 33K samples compared to other TWAS methods which use less than 3k samples. We applied the within-tissue Bonferroni correction to detect significant TWAS genes.
