Consistent patterns of gene coexpression were recently observed in several large cohorts of brain samples from non-demented individuals [24]. The authors discovered several reproducible modules, which they called brain transcriptome modules, and associated some of them with specific brain cell types. Particularly, modules M4/5, M9, M15, and M16 were associated with microglia, oligodendrocytes, astrocytes, and neurons, respectively. We validated the coherence of these modules in the present HBTRC dataset, and found that more than 90% of genes comprising these modules strongly correlated with each other (ρ>0.7) in non-demented subjects. This analysis supports the finding that the latent structure of gene expression in cortex was preserved in our dataset.
