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Chunk #23 — Materials and methods — Meta-analysis

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A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
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We also employed the heterogeneity option of METAL. The METAL heterogeneity analysis requires a second pass of analysis to decide whether observed effect sizes (or test statistics) are homogeneous across samples. The resulting heterogeneity statistic has n–1 degrees of freedom for n samples.