DLPFC samples were obtained from the University of California, Irvine Brain Bank (UCI BB) and assayed in the allelic imbalance study. This cohort includes postmortem brain tissues of 91 subjects (34 CTR, 17 SZ, 19 BD, 21 MDD; 70.3% male, mean age=50.0 ± 13.2 ). Written informed consent was obtained from the next of kin for each subject and the study was reviewed and approved by UCI Institutional Review Board. A psychological autopsy was conducted on all subjects consisting of an extensive review of the medical examiner's conclusions, coroner's investigation, medical and psychiatric records, toxicology results, interviews of the decedents’ next-of-kin, and results of gross neuropathology examinations to exclude possible neurodegenerative disorders. All subjects that were clinically characterized with the psychological autopsy method died suddenly without prolonged agonal state. The human brain dissection and freezing protocol is described in detail elsewhere (Jones et al., 1992). RNA was prepared from 80-100 mg of frozen tissue samples, with Omni Prep Multi-Sample Homogenizer (Omni International, Kennesaw, GA). Total RNA isolation was performed with TRIZOL™ reagent (Invitrogen, Carlsbad, CA), following the manufacturer's instructions. RNA
