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Chunk #3 — Introduction

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Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder.
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Similar to the genetics of AUD and SA, two separate literatures have explored neurocognitive differences between (a) individuals who have attempted suicide to those who have not (Keilp et al., 2013; Richard-Devantoy et al., 2012, 2014) and (b) individuals with AUD (Cabé et al., 2016; Le Berre, 2019; Le Berre et al., 2017) compared to those unaffected with AUD. Those with AUD exhibit deficits in many domains of brain functioning, including neuropsychological performance, and neurophysiological indices (Cabé et al., 2016; Le Berre, 2019; Le Berre et al., 2017). Executive functioning is typically the primary focus of such studies, with a large literature demonstrating that individuals with AUD display poorer executive functioning and atypical neurophysiological profiles (e.g., EEG connectivity) than individuals without AUD (Cardenas et al., 2018; Kamarajan et al., 2020; Mumtaz et al., 2017; Park et al., 2017). Researchers have also examined these areas of brain functioning among individuals who have exhibited suicidal ideation and related mental health problems, such as depression (Keilp et al., 2013; Richard-Devantoy et al., 2012, 2014), though research focused on SA is limited. While no