Despite its strengths, our results should be interpreted within the context of the following limitations. The present analysis uses retrospective reports of substance use and traumatic life events and relies on measures of past year religiosity. The temporality of associations observed in this study is ambiguous; that is, the timing of traumatic exposures and religious service attendance with regard to cannabis use behaviors was not considered in the present study. While this study has largely focused on interpretations that assume trauma exposure and religious service attendance preceded cannabis use problems, previous studies show that substance use and problems may also precede both trauma exposure and religious service practices. Timing of traumatic exposure, religious service attendance, and cannabis use behaviors should be used to further understanding of the temporality of these associations. In addition, this study focused on participants of EA due to the ancestral composition of the discovery cohorts in the Pasman et al. study9. While congruent with what is expected for PRS derived from GWASs with sample sizes and effect sizes similar to those observed in Pasman et al.9,
