Given the relatively low proportion of variance explained by the polygenic personality scores for mood disorders, additional regression analyses were performed to detect the proportion of variance explained by the polygenic personality scores in the personality trait scores themselves. It was tested whether the polygenic N, E, O, A and C scores, as used in the analyses above, significantly predicted the respective N, E, O, A and C trait scores as measured in GAIN-MDD subjects. The polygenic scores explained between 0.1 and 0.4% of the corresponding personality trait scores (P-values between 0.0003 and 0.2) with the best results for polygenic O scores predicting O and the worst results for polygenic A scores predicting A.
