To assess the impact of multiple BP measurements, we compared the P-value and effect size estimates for the previously-described GWAS significant SNPs using one, two, three, four, and all measurements from each individual. We used a set of 67,547 non-Hispanic white individuals, all with ≥5 BP measurements available for this analysis, to keep the sample size identical among comparisons. We also examined the variance explained by a GRS of the previously-described hits assuming previous effect sizes as a function of number of BP measurements.
