mMDD phenotypes in GS:SFHS at all thresholds, however fMDD did not survive multiple testing correction at any PT. PGS derived using information from the GS:SFHS MDD GWAS yielded significant associations with MDD, rMDD, and fMDD phenotypes in UKB at all thresholds, except PT ≤ 0.01—presumably due to the low number of SNPs contributing to the score. However, mMDD did not survive multiple testing correction at any PT. Across all associations, the largest proportion of variance explained in GS:SFHS was 0.66% for fMDD using the MDD polygenic score derived using SNPs at PT ≤ 0.5 using weights from the PGC MDD29 GWAS. The largest proportion of variance explained in UKB was 0.72% for fMDD, again using SNPs at PT ≤ 0.5 using weights from the PGC MDD29 GWAS.
