Addiction related alteration in functional connectivity within the key regions implicated in addiction is demonstrated with resting-state fMRI data acquired from chronic heroin users and non-addicted controls. Compared with controls, chronic heroin users showed increased functional connectivity between nucleus accumbens (NAc) and ventral/rostral anterior cingulate cortex (ACC), and orbital frontal cortex (OFC), and between amygdala and OFC; but reduced functional connectivity between PFC and ACC, and OFC (Figure 3).
