Alcohol use disorder (AUD) is a major public health problem [1–3]. Alcohol is a central nervous system depressant, and high levels of consumption over a long period may alter brain function to promote AUD and damage the brain, in part by altering gene expression levels [4, 5]. Understanding the molecular mechanisms by which alcohol affects the brain is important and might provide clues to the causes of AUD and ways to reverse the impact on the brain of heavy drinking.
