Variation in ADH1B is the best supported molecular genetic risk factor for harmful alcohol use among both EAs and AAs (18). The minor allele (369Cys) of the ADH1B single nucleotide polymorphism (SNP) rs2066702 is associated with a reduced risk of AUD in AAs (3), whereas the minor allele (48His) of rs1229984 is associated with a reduced risk of AUD in EAs (3).
