the minor allele) that are consistent across the two stages. The MAFs and association results for the four SNPs are presented in Table III, along with combined P-values for the two stages using Fisher’s combined probability test [Fisher, 1925]. The lowest P-value observed for the family-based sample is 3.9 × 10−4 (Bonferroni-corrected 1.6 × 10−2) for rs7916403 located within intron 1 of the 5-hydroxytrptamine (serotonin) 7 receptor gene (HTR7) on chromosome 10q23, with a combined P-value score of 1.5 × 10−4 for the two stages. The association for the GWAS sample was notably stronger in the European-American subset (P = 9.97 × 10−4), suggesting potential population-specific ERO effects for this particular locus (see below for additional analyses). The other three significant SNPs from the follow-up association analysis are: rs4907240 downstream from ARID5A on chromosome 2q11; rs13831 located in the 3′ UTR of GNAS1 on chromosome 20q13; and non-synonymous rs2294015 of annexin A13 (ANXA13) on chromosome 8q24.
