Chunk #57 — FINDINGS — Relation of Common Neuropathologic Indices to Clinical AD, MCI, and Level of Cognition AD, MCI, and Level of Cognition — Mixed Pathologies
The combination of AD pathology with cerebral infarcts or Lewy bodies is so common that mixed pathologies are the most common cause of dementia [158]. They are also as common as “pure” AD pathology as a cause of probable AD [33]. In addition, mixed pathology accounts for a substantial proportion of cases of both amnestic and non-amnestic MCI [33]. Consistent with this, all three pathologies are strongly related to multiple cognitive abilities, including episodic memory [159].
