For GWAS catalog data, FUMA (Watanabe et al., 2017) GENE2FUNC module was used to test for enrichment of specific GWAS catalog-associated gene sets for genome-wide significant pleiotropic risk loci. Hypergeometric tests identified any statistical over-representation of genes from the input list in predefined GWAS catalog data. Human protein-coding genes were used as background genes. All identified traits with multiple-testing adjusted P < 0.05 were included as results.
