iPSCs also provide a new way to study sporadic diseases. Prior to the development of iPSC technology, it was impossible to analyze sporadic diseases in cellular models, but now several studies have successfully modeled sporadic neurological diseases54,57,65,73,85,108,125,135,201,202. It has been hypothesized that the pathological mechanisms of sporadic diseases might be the same as familial ones. However, sporadic and familial diseases have significant differences, such as the age of onset and severity, as well as the pathology.
