CLP1 mutations were modeled onto the crystalized yeast structure with Phyre2 (Kelley and Sternberg, 2009). PLINK was used to create autozygosity maps from exome sequence (Purcell et al., 2007). The age of the CLP1 p.R140H mutation was calculated according to published methods (Fu et al., 2013). Additional details can be found in the Extended Experimental Procedures.
