paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #27 — Discussion — Relationship of AUCmax to heritability and disease prevalence when the disease classifier is a genetic risk predictor

Source
The genetic interpretation of area under the ROC curve in genomic profiling.
Embedded
yes

Text

(see solid line Figure 3). However, their representation was of broad sense heritability on the observed scale (i.e. ) which is a little used measure of heritability because of its dependence on disease prevalence [13]. Here we show (Figure 2 and equation 3) the relationship between AUCmax and the more commonly used measure of heritability, the heritability of liability (i.e., ) We show that AUCmax is dependent on both and disease prevalence (i.e. K).