The isoform with cysteine at position 370, called ADH1B*3 (β3-ADH or ADHB*3), differs from ADH1B*1 due to rs2066702. The turnover number for ADH1B*3 is more than 60-fold that of ADH1B*1 in vitro (Table 1); at 17 mM ethanol, ADH1B*3/*3 could oxidize ethanol at about 3 times the rate of ADH1B*1/*1 (interpolated from (Chi et al., 2018)). There are only 2 other coding variants with frequencies over 1%, and these have not, in general, been studied for any ADH (Supplementary Information).
