Some commentators hold extremist views – e.g., that psychiatric diseases arise only from a MRV model (see the Controversies section below). However, empirical results to date are consistent with a place for both MRV and CDCV models. For schizophrenia, bipolar disorder, and autism, the data are consistent with the presence of multiple common variants of subtle effect in some patients and rare variants in others. More examples are likely to emerge with improved technologies and larger sample sizes.
