When moving beyond B6×D2 genotypes, the evidence supporting a reciprocal relationship between consumption and withdrawal has been mixed. Kosobud et al. (1988) found that withdrawal seizure-prone and seizure-resistant (WSP/WSR) selected lines, derived from a heterogeneous stock (HS/Ibg—a cross of eight inbred mouse strains), differed as expected in consumption; when compared to the WSP mice, the WSR mice showed a lower ethanol consumption. The WSP and WSR lines were selected for the severity of the HIC response after chronic ethanol exposure. However, a new selection for the same phenotype and from HS/Ibg animals failed to replicate these results (Metten et al. 1998a). When surveying panels of inbred mouse strains, the reciprocal relationship has been detected for chronic but not acute withdrawal (Crabbe et al. 1983; Belknap et al. 1993; Metten and Crabbe 1994). Chester et al. (2002, 2003) examined the relationship in the alcohol preferring (P) and the high alcohol drinking (HAD1 and HAD2) selected lines versus the non-alcohol preferring (NP) and the low alcohol drinking (LAD1 and LAD2) selected lines. The P and NP lines were derived from outbred Wistar
