Three primary analytical models will be presented: Model 1 examined the unadjusted association with offspring AUD of offspring gender, parental AUD, parental OPD, and parental social status. Model 2 included offspring gender and parental social status in four analyses that evaluated the adjusted association with offspring AUD of each parental risk factor (maternal AUD, paternal AUD, maternal OPD, and paternal OPD). Model 3 included the four parental diagnostic categories and, in addition, adjusted for gender and social status. Secondary analyses based on model 3 tested for potential interactions between offspring gender and parental AUD and OPD with respect to offspring risk of AUD. Significant interaction effects were further examined in separate analyses stratified by gender.
