Chunk #13 — RESULTS — Simulations with Confounding and Polygenicity

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.

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Finally, we modeled studies of a polygenic binary phenotype with case-control ascertainment using a simulated genotypes and a liability threshold model, and verified that LD Score regression is not noticeably biased by case-control ascertainment (Supplementary Table 6).