Chunk #18 — Results — Decreased expression of the δ, ε, and ρ2 but increased expression of the γ1 GABA-A subunit mRNAs in the caudate nucleus of alcoholics
The caudate levels of mRNAs encoding the δ, ϵ, and ρ2 subunits were significantly decreased whereas that of the γ1 subunit was increased in the alcoholics as compared to controls (Figure 4, Table 1). The mRNA levels for the remaining subunits were not altered between the two groups (Figure 4). The significance between the two groups was not affected by age, brain pH, PMI, smoking history, or RQI. No individual in either group consistently expressed genes at higher level than the other individuals in the same group.
