the 95% confidence interval (CI) estimated based on the Hosmer-Lemeshow CI estimation of interaction. AP exceeding zero indicates increased risk due to the two risk factors. Thus, the 95% CI for an AP that does not include a value of zero indicates statistical significance. To account for testing of multiple SNPs as predictors of cannabis dependence, we used the Bonferroni correction and, accordingly, all the tests used a 2-tailed α = 0.017 (0.05/3) significance level for each gene.
