We should, however, point out that abnormal apoptosis might occur in specific developmental period of SZ brains, rather than being a persistent event. While disrupted MAPK signaling was observed, no clear signs of aberrant apoptotic activity were detected in postmortem samples from SZ subjects. In fact, a reduction in apoptosis in brain autopsy samples and in fibroblasts treated with an apoptosis inducer has been found in SZ patients [124, 125], while increased susceptibility to apoptosis was reported in antipsychotic-naïve first-episode SZ patients [31].
