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Chunk #53 — Discussion — An Enrichment of Associations Implies Shared Genetic Etiology

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Alcohol-related genes show an enrichment of associations with a persistent externalizing factor.
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involved in self-regulation, motivation, affect, and reward processing, including the prefrontal cortex, striatum, and limbic systems (Aron, 2011; Bechara, 2005; Coccaro, Sripada, Yanowitch, & Phan, 2011; Jentsch et al., 2014; Jentsch & Taylor, 1999; Patrick et al., 2013; Verdejo-García & Bechara, 2009). Future work in integrative neuroscience including both human and animal model-based approaches may yield paths from genetic variation in this set to functional differences in the brain, and finally to behavior.