Results of backward stepwise logistic regression (LR) analyses are summarized in Table 5. In AA samples, rs1866146 minor allele (C) showed a trend for an effect on risk of CD under either an additive model (P=0.054) or a dominant model (P=0.054). Haplotype C-G-A-C-C, the only haplotype (with a frequency of at least 5%) harboring rs1866146 minor allele (C) in AAs (see Supplementary Material Table S2), increased the risk for CD (P=0.023). In EA samples, rs1866146 minor allele (C) increased the risk for AD, CD, or OD, irrespective of whether an additive or a recessive model was considered [additive model: P=0.003 (AD), P<0.001 (CD), and P=0.003 (OD); dominant model: P=0.001 (AD), P<0.001 (CD), and P=0.002 (OD)]. The most common haplotype, C-G-A-T-T, consisting of major alleles of all five POMC SNPs, reduced the risk for both AD (P=0.007) and CD (P=0.001). Additionally, the third most frequent haplotype, C-G-A-T-C [harboring rs1866146 minor allele (C), see Supplementary Material Table S2], increased the risk for OD (P=0.012).
