MBD, a disease marked by mildly impaired mental status (e.g., confusion) and sometimes by dysarthria (Lee et al. 2011) or ataxia (Arbelaez et al. 2003), is poorly understood but may be related to nutritional deficiencies in addition to chronic alcohol consumption (Kawamura et al. 1985). Traditionally characterized by demyelination and necrosis of the corpus callosum, a number of reports identify cortical lesions in so-called MBD (Ihn et al. 2007; Johkura et al. 2005; Khaw and Heinrich 2006; Namekawa et al. 2013; Tuntiyatorn and Laothamatas 2008; Yoshizaki et al. 2010). Such data, however, represent single case studies and may reflect inaccurate MBD diagnoses. As observed in the pons in CPM, lesions (Clavier et al. 1986) appear hyperintense on T2-weighted images (Bano et al. 2009; Carrilho et al. 2013; Gambini et al. 2003) and hypointense on T1-weighted images (Bano et al. 2009; Carrilho et al. 2013; Kawamura et al. 1985) and often are located along the entire extent of the corpus callosum (Hillbom et al. 2014).
