From the expression data, we identified 282 gene clusters with at least 3 co-regulated genes. The distribution of gene cluster sizes is shown in Figure 2. Many genes present within the same clusters had overlapping, known biological functions, and genes within individual clusters often were syntenic, such as the IFNβ-induced genes IFI44, IFI44L, and IFIT1, -2, and -3, on chromosomal regions 1p31.1 and 10q23-26, contained within a cluster significantly associated with a SNP/locus upstream of RFC3 and STARD13.
