Outside the known FTO intron 1 region, we observed no strong evidence for a second independent signal: When we adjusted each SNP for rs56137030 the most significant SNPs outside of the FTO intron 1 region was a SNP located at position 53710931 (no rs number reported) intronic of the neighbor gene RPGRIP1L (conditional p-value 7.7×10−4) followed by rs8051873 in intron 8 of FTO (conditional p-value 0.0011).