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Chunk #11 — Results

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A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
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Outside the known FTO intron 1 region, we observed no strong evidence for a second independent signal: When we adjusted each SNP for rs56137030 the most significant SNPs outside of the FTO intron 1 region was a SNP located at position 53710931 (no rs number reported) intronic of the neighbor gene RPGRIP1L (conditional p-value 7.7×10−4) followed by rs8051873 in intron 8 of FTO (conditional p-value 0.0011).