Participants underwent a cardiac MDCT exam with four detectors using a standardized protocol as described previously [75]. For participants weighing 100 kg (220 lbs) or greater, the mAs were increased by 25%. The effective radiation exposure for the average participant of each coronary scan was 1.5 mSv for men and 1.9 mSv for women. Participants received two sequential scans. CT images from all study centers were sent electronically to the central CT reading center located at Wake Forest University Health Sciences, Winston Salem, NC, USA.