In total, 44.9% of the translated isoforms (59.9% of the alternative isoforms) would lose either functional or structural domains or functional residues relative to the constitutive isoform. For the “putative” and “novel” biotypes and for those isoforms predicted to be NMD targets, these figures were much higher: 71.5% of all putative transcripts, 62.7% of all novel transcripts, and 79.5% of all predicted NMD transcripts would give rise to isoforms with loss of protein functional or structural information.
