Of our total of 1528 SNPs genotyped, 233 were ancestry informative markers (AIMs) and 1295 were used to capture the underlying genetic structure within our candidate genes. The AIMs were specifically selected to differentiate four parental populations (African, European, American Indian, and East Asian) (68) within each individual and for making precise estimates of coefficient of ancestry (69,70) and principal components (71) for each individual. We have previously genotyped these AIMs in a multi-ethnic sample from the Multiethnic Cohort Diversity Panel (72) and demonstrated the ability of these polymorphisms to identify levels of ancestral populations within a single individual.
