dopamine signaling predicts approximately 11% of the inter-individual variability in reward-related VS reactivity.63 In addition, we recently provided evidence that epigenetic modifications impacting serotonin signaling predict a similar amount of variability in threat-related amygdala reactivity.64 Combining and refining these two strategies in future work may not only allow for a more affordable and reliable way to identify at-risk individuals, but also help uncover novel molecular targets for intervention and prevention.
