The signals at 3q26.31 (Supplementary Figure S5A) and KLF12 (Figure 3C) are with single imputed SNPs of low minor allele frequency (MAF). In 1000 Genomes Phase 3 data from UK subjects (GBR, British residents of England and Scotland), rs117695261 (MAF 0.03) in KLF12 has no r2>0.2 with any other SNP, consistent with the lack of correlated signals in Irish subjects. By contrast, rs150268941 on 3q26.31 is tagged by rs148750402, which was imputed and analyzed in our sample (0.034, p=0.00147, q=0.754464). Direct genotyping of rs150268941 also did not support the observed association (see Supplementary Information), and we did not consider the chromosome 3q26.1 region further.
