Data were obtained from the Missouri Adolescent Female Twin Study cohort, a sample of female adolescent twin pairs and their parents participating in a longitudinal study of the development of alcohol problems and associated psychopathology in adolescent girls and women (MOAFTS; Heath et al., 2002). All twin pairs born in Missouri to Missouri-resident parents between July 1, 1975 and June 30, 1985, where both twins were still living, were identified from birth records. A cohort-sequential design was used with recruitment, over two years, of six-month cohorts of 13, 15, 17, and 19 year-olds. The third and fourth years of data collection added new cohorts of 11- and 13-year-old twins. Ascertainment of families began in January 1995 and continued through December 1998. After exclusion of those families with no maternal diagnostic interview and those with missing data, 1446 twin pairs (~65% of identified families; for details on nonparticipation see Heath et al., 2002) with complete data on all variables were included in the present analysis [831 monozygotic (MZ) pairs, 615 dizygotic (DZ) pairs]. 13% of the sample classified themselves as minority